Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association

Autor: Shun Nakagama, Katherine Candray, Tasuku Yamamoto, Yuta Tsugeno, Yu Nakagama, Yasutoshi Kido, Yuko Nitahara, Yasuhiro Maejima, Tetsuo Sasano
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: ESC Heart Failure, Vol 9, Iss 1, Pp 761-765 (2022)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.13771
Popis: Abstract We report on a 52‐year‐old Brazilian immigrant woman with past histories of chronic kidney disease and uveitis, presenting with symptomatic atrioventricular block. Her country of origin being endemic for Trypanosoma cruzi infection, we suspected Chagas disease as the aetiology, diagnosis of which was confirmed by serological tests. Further systemic workup identified an emerging nodular lesion in the lung, which turned out to be a sarcoid epithelioid granuloma on biopsy. Involvement of the kidneys and eyes was suggestive of systemic extension of the lung sarcoidosis. Although imaging modalities did not detect inflammatory foci in the myocardium, the rare coexistence of histologically proven sarcoidosis raised the intriguing concept of cardiac manifestation having arisen from two possibly overlapping aetiologies: Chagas disease and cardiac sarcoidosis. The case highlights a treatment dilemma increasingly likely to be encountered in this globalized world, and also raises the potential, but intriguing, association of these two diseases.
Databáze: Directory of Open Access Journals