A high-throughput response to the SARS-CoV-2 pandemic

Autor: Lynn Rasmussen, Shalisa Sanders, Melinda Sosa, Sara McKellip, N. Miranda Nebane, Yohanka Martinez-Gzegozewska, Andrew Reece, Pedro Ruiz, Anna Manuvakhova, Ling Zhai, Brooke Warren, Aliyah Curry, Qinghua Zeng, J. Robert Bostwick, Paige N. Vinson
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: SLAS Discovery, Vol 29, Iss 5, Pp 100160- (2024)
Druh dokumentu: article
ISSN: 2472-5552
DOI: 10.1016/j.slasd.2024.100160
Popis: Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that has been gained. The response to the pandemic was rapid and highly resourced; it was also built upon a foundation of decades of federally funded basic and applied research. Laboratories in government, pharmaceutical, academic, and non-profit institutions all played roles in advancing pre-2020 discoveries to produce clinical treatments. This perspective provides a summary of how the development of high-throughput screening methods in a biosafety level 3 (BSL-3) environment at Southern Research Institute (SR) contributed to pandemic response efforts. The challenges encountered are described, including those of a technical nature as well as those of working under the pressures of an unpredictable virus and pandemic.
Databáze: Directory of Open Access Journals