Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J
| Autor: | Zahra Nazeri, Shirin Azizidoost, Maryam Cheraghzadeh, Asma Mohammadi, Alireza Kheirollah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Avicenna Journal of Phytomedicine, Vol 11, Iss 5, Pp 473-483 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2228-7930 2228-7949 |
| DOI: | 10.22038/ajp.2021.17834 |
| Popis: | Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear. Here, we investigated the beneficial effect of aqueous extract of garlic and allicin on lipid profile and the main players involved in brain cholesterol homeostasis including ABCA1, HMG-CoA reductase, and CYP46A1 in both C57BL/6J mice brain and astrocytes. Materials and Methods: Thirty mice were divided into control and garlic groups. Garlic group was fed with the aqueous extract of garlic. Serum lipids were measured and brain protein levels of ABCA1, HMGCR, and CYP46A1 were determined by western blotting. Changes in these proteins expression were also studied in the presence of allicin in cultured astrocytes. Results: A moderate decrease in serum total cholesterol and a significant increase in plasma HDL-C levels (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|