Anti-p53 autoantibody as early diagnostic and prognostic marker of bronchogenic carcinoma in smokers
| Autor: | Mohammed B.M Sofyan, Mohammad S.A Bakheet, Mostafa M.M Alomairi, Hamada Kawshtysayed, Sameh Salahelden |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Al-Azhar Assiut Medical Journal, Vol 16, Iss 3, Pp 286-295 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1687-1693 82983526 |
| DOI: | 10.4103/AZMJ.AZMJ_85_18 |
| Popis: | Background Mutations in the tumor protein 53 (TP53) gene can lead to expression of mutant p53 proteins that accumulate in cancer cells and can induce circulating p53 antibodies in patients with cancer. Neoplastic transformation leads to elevated plasma sialic acid concentration through shedding or secreting of sialic acid from tumor cell surfaces. Our work aims to evaluate the presence and prognostic role of these antibodies and sialic acid in patients with lung cancer. Patients and methods A total of 30 patients with lung cancer (five patients were presented with stage I, 10 patients with stage II, 10 patients with stage III, and five patients with stage IV) and 60 with nonmalignant disorders (30 smokers and 30 apparently healthy individuals) were evaluated for p53 antibodies by enzyme-linked immunosorbent assay and sialic acid by colorimetric methods. Results Anti-p53 antibodies and sialic acids levels in patients with bronchogenic carcinoma were significantly higher than smokers, and both levels were significantly higher than healthy controls (P |
| Databáze: | Directory of Open Access Journals |
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