Comparative study of in vitro activity of tedizolid and linezolid against Mycobacterium avium complex.

Autor: Eduardo Marfil, Pilar Ruiz, Luis Martínez-Martínez, Manuel Causse
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Global Antimicrobial Resistance, Vol 30, Iss , Pp 395-398 (2022)
Druh dokumentu: article
ISSN: 2213-7165
DOI: 10.1016/j.jgar.2022.07.012
Popis: Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a macrodilution assay with the Bactec-MGIT-960. Methods: A total of 37 clinical isolates of MAC were included in the study. Reference broth microdilution was performed according to CLSI guidelines in a range of concentrations from 64 to 0.064 mg/L. Macrodilution was performed with the Bactec-MGIT-960 system. The cut-off points defined by CLSI for linezolid (resistant: > 16 mg/L, intermediate: 16 mg/L, susceptible:
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