| Autor: |
Samir Ghosh, A. Sanjeev Kumar, G. N. Mehta |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 27 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.6.27 |
| Popis: |
An efficient synthesis of the angiotensin-II inhibitor valsartan (Diovan®) is presented. Directed ortho-metalation of 5-phenyl-1-trityl-1H-tetrazole (6) and its Negishi coupling with aryl bromide 5 are the key steps of the synthesis. This method overcomes many of the drawbacks associated with previously reported syntheses. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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