| Autor: |
Ying Lv, Li Chen, Xinghan Yun, Kun Li, Shengjiao Yan |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Green Synthesis and Catalysis, Vol 5, Iss 2, Pp 94-101 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5549 |
| DOI: |
10.1016/j.gresc.2022.10.003 |
| Popis: |
A novel method for the preparation of highly functionalized 4-oxo-3-(1H-pyrrol-3-yl)-4H-chromenes (OPCMs) from 3-formylchromones and α-isocyanoacetates via an unprecedented three-component [1 + 1 + 3] cycloaddition reaction in one pot was developed. The three-component cascade reaction was enabled by refluxing a mixture of the substrates in 1,4-dioxane in the presence of Ag2CO3 as a Lewis acid promoter. As a result, a series of functionalized pyrroles (OPCMs, 3), was prepared regioselectively and in high yields (80%–88%) through the formation of three bonds. This protocol can be used in the synthesis of OPCMs rather than through conventional, multi-step reactions and is suitable for both combinatorial and parallel syntheses of pyrroles. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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