Direct quality control of glycoengineered erythropoietin variants
| Autor: | Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 44255942 |
| DOI: | 10.1038/s41467-018-05536-3 |
| Popis: | Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin. |
| Databáze: | Directory of Open Access Journals |
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