An investigational protocol of intraoperative radiotherapy in the treatment of early-stage breast cancer: partial results from the Hospital Israelita Albert Einstein

Autor: Silvio Eduardo Bromberg, Maria Augusta Bernardini, Antonio Luis Frasson, Jairo Wagner, Filadelfico Venco, Rodrigo Hanriot, Artur Katz, Sergio Simon
Jazyk: English<br />Portuguese
Rok vydání: 2007
Předmět:
Zdroj: Einstein (São Paulo), Vol 5, Iss 2, Pp 105-110 (2007)
Druh dokumentu: article
ISSN: 1679-4508
Popis: Objective: To describe and assess the experience of the HospitalAlbert Einstein on the treatment of early-stage breast cancer withintraoperative radiotherapy. Methods: Twenty-two patients withinvasive breast cancer, older than 45 years, with tumors ≤ 2.5 cm andwith clinically normal axillary lymph nodes at intraoperative evaluation,who underwent quadrantectomy with sentinel lymph node biopsyand intraoperative radiotherapy. Clinical characteristics, histologicalfindings and intraoperative radiotherapy technique were assessed.Results: The mean age of patients was 60.4 years and 90.9% of themwere post-menopausal. Mean tumor diameter was 1.5 cm, with 81%being of the invasive ductal type; 89% were hormonal receptor positiveand Her-2/neu negative. Clinical stage I was found in 86.4%. Sentinellymph node was negative in 81.8%. The radiation dose was 21 Gy inall patients, with a mean radiation time of 9.65 minutes, mean surgerytime of 234 minutes and mean depth of breast tissue irradiated of 1.72cm. Conclusion: Our preliminary results are similar to those of theliterature, demonstrating that intraoperative radiotherapy is a feasibletechnique in our setting, safe and equivalent to conventional externalbeam radiotherapy, with potential radiobiological, technical, clinical,psychosocial and economic advantages.
Databáze: Directory of Open Access Journals
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