Recent advances in tissue repair of the blood-brain barrier after stroke

Autor: Liujie Qi, Fei Wang, Xiaojing Sun, Hang Li, Kun Zhang, Jingan Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Tissue Engineering, Vol 15 (2024)
Druh dokumentu: article
ISSN: 2041-7314
20417314
DOI: 10.1177/20417314241226551
Popis: The selective permeability of the blood-brain barrier (BBB) enables the necessary exchange of substances between the brain parenchyma and circulating blood and is important for the normal functioning of the central nervous system. Ischemic stroke inflicts damage upon the BBB, triggering adverse stroke outcomes such as cerebral edema, hemorrhagic transformation, and aggravated neuroinflammation. Therefore, effective repair of the damaged BBB after stroke and neovascularization that allows for the unique selective transfer of substances from the BBB after stroke is necessary and important for the recovery of brain function. This review focuses on four important therapies that have effects of BBB tissue repair after stroke in the last seven years. Most of these new therapies show increased expression of BBB tight-junction proteins, and some show beneficial results in terms of enhanced pericyte coverage at the injured vessels. This review also briefly outlines three effective classes of approaches and their mechanisms for promoting neoangiogenesis following a stroke.
Databáze: Directory of Open Access Journals
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