Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia

Autor:	Tiffany T. Oommen, Kelly Sun, Javier Barranco-Trabi, Jeffrey Berenberg, Myungjin Kim
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Case Reports in Nephrology, Vol 2023 (2023)
Druh dokumentu:	article
ISSN:	2090-665X
DOI:	10.1155/2023/9160326
Popis:	PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury and hypoxic respiratory failure that was responsive to corticosteroids suggestive of immunotoxicity from pembrolizumab.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6d368c1f06014ab0868b8dacf6089474 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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