Colchicine as an Adjuvant Therapy for Coronary Artery Disease: A Systematic Review
| Autor: | Nobian Andre, Patricia Renata, Muhamad Hafiz Mahruzza, Rony Marethianto Santoso |
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| Jazyk: | English<br />Indonesian |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Majalah Kardiologi Indonesia, Vol 1, Iss 1 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0126-3773 2620-4762 |
| DOI: | 10.30701/ijc.990 |
| Popis: | Background:Inflammation plays a significant role in atherosclerosis at all phases. Colchicine is a pleiotropic anti-inflammatory agent that may be beneficial in various stages of coronary artery disease (CAD). Methods:We searched for literatures in PubMed, Cochrane Library, ScienceDirect, and Proquest regarding the use of colchicine on top of current optimal medical therapy for CAD. Results: Twelve studies were identified: three studies in stable CAD patients and the remaining nine assessed in acute coronary syndrome (ACS) and post-ACS patients. The majority of studies used a colchicine dose of 0.5 mg/day. Adjuvant colchicine of 0.5 mg daily reduced the risk of developing ACS, cardiac arrest, or ischemic stroke in stable CAD: HR (hazard risk) 0.33 (95% CI 0.18-0.59), p |
| Databáze: | Directory of Open Access Journals |
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