Inhibitory effect of Salidroside on the interaction between human platelets and breast cancer MDA-MB-468 cells
| Autor: | Yihan SHAO, Xiaobao SHAO, Weina ZHU, Xin CHEN, Lin ZHOU, Peiyuan ZHU |
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| Jazyk: | čínština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Zhongguo shuxue zazhi, Vol 37, Iss 7, Pp 754-760 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1004-549X 1004-549x |
| DOI: | 10.13303/j.cjbt.issn.1004-549x.2024.07.006&lang=en |
| Popis: | Objective To study the effect of Salidroside(Sal) on platelet activation and aggregation and the interaction between human platelets and MDA-MB-468 cells of breast cancer. Methods Human platelets were collected, platelet suspension was prepared, and platelets were treated with different concentrations of Sal. The effects of Sal on platelet activation and aggregation were detected by thromboelastogram(TEG) and flow cytometry. Breast cancer MDA-MB-468 cells were cultured in vitro, and human platelets were treated with different concentrations of Sal, and then activated by thrombin. The effects of Sal on the interaction between platelets and MDA-MB-468 cells were analyzed by adhesion test and scratch test. Results TEG detection: The ADP inhibition rate in the blank control group was (10.97±12.69)%, and the ADP inhibition rate in all Sal intervention groups was higher than that in the blank control group (P |
| Databáze: | Directory of Open Access Journals |
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