Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review

Autor: Nicholas D. Jakowenko, Brian J. Kopp, Brian L. Erstad
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American College of Emergency Physicians Open, Vol 3, Iss 4, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2688-1152
DOI: 10.1002/emp2.12777
Popis: Abstract Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and different categories of spontaneous intracranial hemorrhage. We also discuss differences between setting (hospital vs pre‐hospital), dosing and timing strategies, and other logistical challenges surrounding optimal use of TXA for isolated intracranial hemorrhage. Last, we hope to provide guidance for clinicians when considering the use of TXA in a patient with traumatic or non‐traumatic intracranial hemorrhage based on appraisal of the available literature as well as some potential ideas for future research in this area.
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