| Autor: |
Yasuyuki Shiraishi, Eisuke Amiya, Masaru Hatano, Toshiomi Katsuki, Chie Bujo, Masaki Tsuji, Daisuke Nitta, Hisataka Maki, Junichi Ishida, Yukie Kagami, Miyoko Endo, Mitsutoshi Kimura, Masahiko Ando, Shogo Shimada, Osamu Kinoshita, Minoru Ono, Issei Komuro |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
ESC Heart Failure, Vol 7, Iss 4, Pp 1842-1849 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2055-5822 |
| DOI: |
10.1002/ehf2.12749 |
| Popis: |
Abstract Aims Nephrotoxicity of calcineurin inhibitors (CNIs) is associated with adverse events in patients undergoing heart transplant (HTx), although studies directly comparing tacrolimus (TAC) versus cyclosporin A (CsA), especially in combination with everolimus and low‐dose CNIs approach, are limited. Thus, we sought to investigate the associations of TAC and CsA with clinical outcomes in HTx recipients, with specific focus on renal function. Methods and results From August 2007 to February 2017, 72 consecutive patients (39 treated with TAC vs. 33 with CsA) receiving de novo HTx in a single transplant centre were retrospectively evaluated. We used the instrumental variable method to account for unmeasured confounding. The study outcomes were percentage change in estimated glomerular filtration rates (eGFR) (safety endpoint) and biopsy‐proven acute rejection (efficacy endpoint) within the first year after HTx. The enrolled patients (median age 40 years) were predominantly men (68%). There were no significant differences in baseline characteristics, including eGFR (64.8 [45.7–96.4] mL/min/1.73 m2 in TAC vs. 65.6 [57.9–83.0] mL/min/1.73 m2 for CsA; P = 0.48), other than sex (male, 49% for TAC vs. 91% for CsA; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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