Outcome Measures in Relapsing-Remitting Multiple Sclerosis: Capturing Disability and Disease Progression in Clinical Trials

Autor:	Amy M. Lavery, Leonard H. Verhey, Amy T. Waldman
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Neurology. Diseases of the nervous system RC346-429
Zdroj:	Multiple Sclerosis International, Vol 2014 (2014)
Druh dokumentu:	article
ISSN:	2090-2654 2090-2662
DOI:	10.1155/2014/262350
Popis:	Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that manifests as acute relapses and progressive disability. As a primary endpoint for clinical trials in MS, disability is difficult to both characterize and measure. Furthermore, the recovery from relapses and the rate of disability vary considerably among patients. Given these challenges, investigators have developed and studied the performance of various outcome measures and surrogate endpoints in MS clinical trials. This review defines the outcome measures and surrogate endpoints used to date in MS clinical trials and presents challenges in the design of both adult and pediatric trials.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6cea79a1411542e1b6fe07cc1e108b01 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF