| Autor: |
Zoran Milosavljević, Snežana Jančić, Katarina Katić, Miodrag Radović, Zoran Pop-Trajković, Slaviša Jančić |
| Jazyk: |
angličtina |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Acta Medica Medianae, Vol 41, Iss 6, Pp 11-20 (2002) |
| Druh dokumentu: |
article |
| ISSN: |
0365-4478 |
| Popis: |
Regarding scarce studies about the G immunoglobulin distribution both in the normal and in the tumor tissue of the ovary, the aim of the paper is to examine immuno-expression of the IgG in benign, "borderline" and malign ovary tumors.The operative material that was first being fixed in 10% formaldehyde, treated in the routine way and molded in paraffin was used. The method that were applied upon the sections of 5 micrometers in thickness were the routine H&E method for pathohistological tumor diagnostis, the mucinohistochemical AB-PAS (pH 2,5) method for verification of mucinous tumors of the ovary and the immunocytochemical SAB technique with anti-IgG antibodies (1:800).No IgG-immunoreactive cells were verified in benign cells while in the "borderline" lesions rare and individual tumor cells contain the IgG but their immuno-reactivity is of poor intensity; sometimes the IgG was only present in slight traces. The intensive IgG expression was found in polymorphous, hyperchromium cells of adenocarcinoma; in these cases, the deposits of this marker were conspicuously prominent in malign tumors of poorer differentiation. Mononucleous inflammatory cells and macrophages of the stroma of both benign and malign cells also show intensive immunoreaction to the IgG.The authors discuss anti tumor role of the IgG in immunity and they suggest that the immunoglobulin G should also be introduced into PAN marker family for screening ovary tumor analyzes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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