Reticulum vs Inclusions: A Learning Experience in Haemoglobin H Disease
| Autor: | Hanaganahalli B Sridevi, Anupama Hegde, Prashantha Balanthimogru, Urmila N. Khadilkar, Shrijeet Chakraborti |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 9, Iss 10, Pp ED17-ED19 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X 38124742 |
| DOI: | 10.7860/JCDR/2015/13649.6657 |
| Popis: | Haemoglobin H disease, also known as the alpha-thalassaemia is characterized by the presence of HbH inclusions in red blood cells, detectable on supra-vital stain. We present a case of a previously asymptomatic 31-year-old male, who insidiously developed anaemia and had prominent splenomegaly. Peripheral smear examination revealed microcytic hypochromic anaemia with numerous spherocytes and moderate polychromasia. In reticulocyte preparation with Brilliant cresyl blue, HbH inclusions were mistakenly identified as granulofilamentous reticulum of reticulocytes, giving a spuriously high reticulocyte percentage. After the literature review, repeat assessment was performed and with the aid of high performance liquid chromatography result, it was possible to delineate the HbH inclusions. |
| Databáze: | Directory of Open Access Journals |
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