HEPATITIS B IN PREGNANCY – MODERN APPROACHES TO SCREENING AND PREVENTION OF VERTICAL TRANSMISSION OF INFECTION
| Autor: | Кира Борисовна Мозес, Вадим Гельевич Мозес, Игорь Сергеевич Захаров, Светлана Ивановна Елгина, Елена Владимировна Рудаева |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Мать и дитя в Кузбассе, Vol 20, Iss 3, Pp 10-17 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1991-010X 2542-0968 |
| Popis: | The aim of the research – to carry out an analytical review of modern sources of scientific literature covering the issues of screening and prevention of complications in pregnant women with hepatitis В. Materials and methods. The analysis of 74 domestic and foreign sources of literature on this topic. Results. According to the scientific analysis, new data on the prevalence of hepatitis В in pregnancy in the Russian Federation and in the world have been obtained. The review describes possible complications of pregnancy and childbirth associated with hepatitis В, assessed the risk of vertical transmission of infection, highlighted the effectiveness of screening this disease and the tactics of managing pregnancy in infected women. Conclusion. The high prevalence of hepatitis B during pregnancy makes it an urgent problem. The analysis suggests that conducting active-passive immunization against newborns from HBeAg-positive mothers is an effective way to prevent neonatal transmission of hepatitis B. To prevent immunoprophylaxis in HBeAg-positive women with high levels of HBV DNA (> 200,000 IU/ml) and or with an HBsAg level above 4 log10 ME/ml, chemoprophylaxis with lamivudine, tenofovir and telbivudine is recommended in the third trimester of pregnancy, among which tenofovir is preferred. |
| Databáze: | Directory of Open Access Journals |
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