Emerging methylation-based approaches in microbiome engineering

Autor: Changhee Won, Sung Sun Yim
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 2731-3654
DOI: 10.1186/s13068-024-02529-x
Popis: Abstract Bacterial epigenetics, particularly through DNA methylation, exerts significant influence over various biological processes such as DNA replication, uptake, and gene regulation in bacteria. In this review, we explore recent advances in characterizing bacterial epigenomes, accompanied by emerging strategies that harness bacterial epigenetics to elucidate and engineer diverse bacterial species with precision and effectiveness. Furthermore, we delve into the potential of epigenetic modifications to steer microbial functions and influence community dynamics, offering promising opportunities for understanding and modulating microbiomes. Additionally, we investigate the extensive diversity of DNA methyltransferases and emphasize their potential utility in the context of the human microbiome. In summary, this review highlights the potential of DNA methylation as a powerful toolkit for engineering microbiomes.
Databáze: Directory of Open Access Journals
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