Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

Autor: Dong Ha Kim, HyeongRyul Kim, Yun Jung Choi, Seon Ye Kim, Jung-Eun Lee, Ki Jung Sung, Young Hoon Sung, Chan-Gi Pack, Min-kyo Jung, Buhm Han, Kunhee Kim, Woo Sung Kim, Soo Jeong Nam, Chang-Min Choi, Miyong Yun, Jae Cheol Lee, Jin Kyung Rho
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-13 (2019)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
DOI: 10.1038/s12276-019-0295-2
Popis: Lung cancer: Immune suppressant protein promotes tumor growth An immune suppressant protein expressed by non-small cell lung cancer cells (NSCLC) to facilitate tumor growth could be a valuable therapeutic target. NSCLC is often diagnosed at advanced stages, making treatment challenging. Therapies that inhibit an immune suppressant protein called programmed cell death ligand-1 (PD-L1) have shown promise for other cancers, but how PD-L1 interacts with host and tumor cells in NSCLC needs clarification. In experiments on human cell lines and mice, Jae Cheol Lee and Jin Kyung Rho at the University of Ulsan in Seoul, South Korea, and co-workers found that microvesicles (or ‘exosomes’) released by NSCLC cells carry PD-L1, which interacts with tumor-infiltrating immune cells, inhibiting their activity. The amount of PD-L1 in exosomes directly correlates with PD-L1 expression levels on tumor cell surfaces, providing a useful indication of disease activity.
Databáze: Directory of Open Access Journals
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