| Autor: |
Sheu Jiunn-Jye, Lin Kun-Chen, Tsai Ching-Yen, Tsai Tzu-Hsien, Leu Steve, Yen Chia-Hung, Chen Yung-Lung, Chang Hsueh-Wen, Sun Cheuk-Kwan, Chua Sarah, Yang Jenq-Lin, Yip Hon-Kan |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Journal of Translational Medicine, Vol 10, Iss 1, p 164 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1479-5876 |
| DOI: |
10.1186/1479-5876-10-164 |
| Popis: |
Abstract Background and aim Procedural failure and untoward clinical outcomes after surgery remain problematic in critical limb ischemia (CLI) patients. This study tested a clopidogrel-cilostazol combination treatment compared with either treatment alone in attenuating CLI and improving CLI-region blood flow in rats. Methods Male Sprague–Dawley rats (n = 40) were equally divided into five groups: control, CLI induction only, CL I + cilostazol (12.0 mg/day/kg), CLI + clopidogrel (8.0 mg/kg/day) and CLI + combined cilostazol-clopidogrel. After treatment for 21 days, Laser Doppler imaging was performed. Results On day 21, the untreated CLI group had the lowest ratio of ischemic/normal blood flow (p Conclusion Combined cilostazol-clopidogrel therapy is superior to either agent alone in improving ischemia in rodent CLI. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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