| Autor: |
Joseph A. Miccio, Wesley J. Talcott, Timil Patel, Henry S. Park, Michael Cecchini, Ronald R. Salem, Sajid A. Khan, Stacey Stein, Jeremy S. Kortmansky, Jill Lacy, Amol Narang, Joseph Herman, Salma K. Jabbour, Christopher L. Hallemeier, Kimberly Johung, Krishan R. Jethwa |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Clinical and Translational Radiation Oncology, Vol 27, Iss , Pp 15-23 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6308 |
| DOI: |
10.1016/j.ctro.2020.12.003 |
| Popis: |
Purpose: Margin-negative (R0) resection is the only potentially curative treatment for patients with pancreatic ductal adenocarcinoma (PDAC). Pre-operative multi-agent chemotherapy alone (MAC) or MAC followed by pre-operative radiotherapy (MAC + RT) may be used to improve resectability and potentially survival. However, the optimal pre-operative regimen is unknown. Methods: Patients with non-metastatic PDAC from 2006 to 2016 who received pre-operative MAC or MAC + RT before oncologic resection were identified in the National Cancer Database. Univariable and multivariable (MVA) associates with R0 resection were identified with logistic regression, and survival was analyzed secondarily with the Kaplan Meier method and Cox regression analysis. Results: 4,599 patients were identified (MAC: 3,109, MAC + RT: 1,490). Compared to those receiving MAC, patients receiving MAC + RT were more likely to have cT3-4 disease (76% vs 64%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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