Infarct in the Heart: What’s MMP-9 Got to Do with It?
| Autor: | Mediha Becirovic-Agic, Upendra Chalise, Michael J. Daseke, Shelby Konfrst, Jeffrey D. Salomon, Paras K. Mishra, Merry L. Lindsey |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Biomolecules, Vol 11, Iss 4, p 491 (2021) |
| Druh dokumentu: | article |
| ISSN: | 11040491 2218-273X |
| DOI: | 10.3390/biom11040491 |
| Popis: | Over the past three decades, numerous studies have shown a strong connection between matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left ventricle remodeling and dysfunction. Despite this fact, clinical trials using MMP-9 inhibitors have been disappointing. This review focuses on the roles of MMP-9 in MI wound healing. Infiltrating leukocytes, cardiomyocytes, fibroblasts, and endothelial cells secrete MMP-9 during all phases of cardiac repair. MMP-9 both exacerbates the inflammatory response and aids in inflammation resolution by stimulating the pro-inflammatory to reparative cell transition. In addition, MMP-9 has a dual effect on neovascularization and prevents an overly stiff scar. Here, we review the complex role of MMP-9 in cardiac wound healing, and highlight the importance of targeting MMP-9 only for its detrimental actions. Therefore, delineating signaling pathways downstream of MMP-9 is critical. |
| Databáze: | Directory of Open Access Journals |
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