Ischemic stroke in patients with type 2 diabetes: Relationship between decreased insulin sensitivity and fibrinolysis impairment
| Autor: | Jotić Aleksandra, Lalić Nebojša M., Čovičković-Šternić Nadežda, Kostić Vladimir, Lalić Katarina, Miličić Tanja, Mijailović Milija, Lukić Ljiljana, Rajković Nataša, Maćešić Marija, Aleksić Sandra, Seferović-Mitrović Jelena, Stošić Ljubica, Zamaklar Miroslava |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", Vol 16, Iss 41, Pp 25-49 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1821-1925 2406-131X |
| DOI: | 10.5937/medgla1141025J |
| Popis: | The role of insulin sensitivity (IS), as well as the association of IS with fibrinolysis impairment, in the occurrence of ischemic stroke, has not been clarified. The study was aimed to analyze IS, plasma insulin (PI) and plasminogen activator inhibitor (PAI)-1 levels in 34 type 2 diabetics (T2D) with ischemic stroke (group A), 30 T2D without ischemic stroke (group B), 33 nondiabetics with ischemic stroke (group C) and 33 healthy controls (group D). Ischemic stroke was confirmed by clinical and neuroimaging criteria. IS levels were determined by the minimal model analysis (Si index). Plasma insulin levels were measured by radioimmunoassay and PAI-1 activity was performed by the plasminogen chromogenic plasmin substrate assay. We found that Silevels were significantly lower in group A vs. B (1.17+/-0.66 vs. 2.79+/-0.62 min-1/mU/Lx104; p |
| Databáze: | Directory of Open Access Journals |
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