Wood-Derived Dietary Fibers Promote Beneficial Human Gut Microbiota

Autor: Sabina Leanti La Rosa, Vasiliki Kachrimanidou, Fanny Buffetto, Phillip B. Pope, Nicholas A. Pudlo, Eric C. Martens, Robert A. Rastall, Glenn R. Gibson, Bjørge Westereng
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: mSphere, Vol 4, Iss 1 (2019)
Druh dokumentu: article
ISSN: 2379-5042
DOI: 10.1128/mSphere.00554-18
Popis: ABSTRACT Woody biomass is a sustainable and virtually unlimited source of hemicellulosic polysaccharides. The predominant hemicelluloses in softwood and hardwood are galactoglucomannan (GGM) and arabinoglucuronoxylan (AGX), respectively. Based on the structure similarity with common dietary fibers, GGM and AGX may be postulated to have prebiotic properties, conferring a health benefit on the host through specific modulation of the gut microbiota. In this study, we evaluated the prebiotic potential of acetylated GGM (AcGGM) and highly acetylated AGX (AcAGX) obtained from Norwegian lignocellulosic feedstocks in vitro. In pure culture, both substrates selectively promoted the growth of Bifidobacterium, Lactobacillus, and Bacteroides species in a manner consistent with the presence of genetic loci for the utilization of β-manno-oligosaccharides/β-mannans and xylo-oligosaccharides/xylans. The prebiotic potential of AcGGM and AcAGX was further assessed in a pH-controlled batch culture fermentation system inoculated with healthy adult human feces. Results were compared with those obtained with a commercial fructo-oligosaccharide (FOS) mixture. Similarly to FOS, both substrates significantly increased (P
Databáze: Directory of Open Access Journals