A 12-month prospective exploratory study of muscle and fat characteristics in individuals with mild-to-moderate hip osteoarthritis

Autor: Aderson Loureiro, Maria Constantinou, Belinda Beck, Rod S. Barrett, Laura E. Diamond
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-9 (2019)
Druh dokumentu: article
ISSN: 1471-2474
DOI: 10.1186/s12891-019-2668-z
Popis: Abstract Background Reductions in lower extremity muscle strength, size and quality and increased fat content have been reported in advanced hip osteoarthritis (OA). Whether these differences are also evident at earlier stages of the disease and the extent to which they might develop over time is unclear. The main purpose of this 12-month exploratory prospective study was to compare changes in muscle and fat characteristics in individuals with mild-to-moderate hip OA and healthy controls. Methods Fourteen individuals with mild-to-moderate symptomatic and radiographic hip OA (n = 9 unilateral; n = 5 bilateral), and 15 healthy controls similar in age and sex without symptoms or radiographic hip OA were assessed at baseline and at 12-month follow-up. Maximal voluntary isometric strength of the hip and knee muscle groups was assessed using an isokinetic dynamometer. Lower extremity lean and fat mass were assessed using dual-energy x-ray absorptiometry, and thigh muscle and fat areas and thigh muscle density were assessed using peripheral quantitative computed tomography. Results Knee extension (p = 0.01), hip extension (p
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