Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites – case report and a literature review
| Autor: | Ewa Anna Kosakowska, Rafal Stec, Radoslaw Charkiewicz, Marta Skoczek, Lech Chyczewski |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 597-602 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0239-8508 1897-5631 |
| Popis: | In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment ofthe KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results ofthe analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatictumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located inthe colon and metastatic changes in the liver. |
| Databáze: | Directory of Open Access Journals |
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