Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Autor: Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019)
Druh dokumentu: article
ISSN: 2051-5960
DOI: 10.1186/s40478-019-0855-7
Popis: Abstract To identify pathogenetic markers and potential drivers of different lesion types in the white matter (WM) of patients with progressive multiple sclerosis (PMS), we sequenced RNA from 73 different WM areas. Compared to 25 WM controls, 6713 out of 18,609 genes were significantly differentially expressed in MS tissues (FDR
Databáze: Directory of Open Access Journals
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