Effect of Atorvastatin on Pentylenetetrazol-Induced Threshold Seizures in Gonadectomized Male Mice
| Autor: | S Azizi, N Heydarieh, F Jmalu |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 24, Iss 7, Pp 527-537 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2228-5741 2228-5733 |
| Popis: | Introduction: Epilepsy is a central nervous system disorder that appears as sudden convulsions, and transient, repetitive and unpredictable movement, with sensory-motor and autonomic sources. Statins are a group of blood cholesterol-lowering drugs. According to the results of the anti-inflammatory and vasoprotective effects of statins on cultured brain cells (astrocytes and microglia) and endothelial cells, the purpose of this study was investigating the effect of atorvastatin on pentilentetrazole-induced seizures in gonadectomized male mice. Methods: 36 male NMRI mice, weighting 30-35 g were used in the study. The mice were divided into two groups (Each group consisted of 18 mice : healthy and gonadectomized groups. The surgical removal of the testicles was gonadectomy and injections were given intraperitoneally. In gonadectomized group, an operation to remove the testicles was done. The DMSO group (0/3 cc) and treatment group were received Atorvastatin (10 mg/kg) intraperitoneally and then 30 minutes after that they received PTZ (80 mg/kg) injection. All injections were administered intraperitoneally. After injection of PTZ- duration of seizure onset (threshold) was recorded. The data were analyzed by one way variance analysis and Tukey’s test using SPSS (p |
| Databáze: | Directory of Open Access Journals |
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