| Autor: |
Abul Hasanat, Tanvir Ahmad Chowdhury, Mohammad Shah Hafez Kabir, Mohammed Sohel Chowdhury, Md. Nazim Uddin Chy, Jackie Barua, Nishan Chakrabarty, Arkajyoti Paul |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Medicines, Vol 4, Iss 4, p 88 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2305-6320 |
| DOI: |
10.3390/medicines4040088 |
| Popis: |
Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis. Methods: Antinociceptive activity was determined by acetic acid-induced writhing and formalin-induced licking test in mice. Then, molecular docking study was performed to identify compounds having maximum activity against the COX-1 enzyme using Schrödinger Maestro (version 10.1) to determine docking fitness. Results: A preliminary phytochemical analysis of Met.MD revealed that it contained alkaloids, carbohydrates, phenols, flavonoids, tannins, and terpenoids. Met.MD exhibited a dose-dependent and statistically significant antinociceptive activity in the acetic acid and formalin test at the doses of 200 and 400 mg/kg. In addition, our docking study showed that macarangin had the best fitness score of −5.81 with COX-1 enzyme among six major compounds of M. denticulata. Conclusions: Results of the present study confirmed the potential antinociceptive activity of M. denticulata leaf extract in both in vivo and in silico models. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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