Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors

Autor: Amanda Rosewell Shaw, Caroline E. Porter, Tiffany Yip, Way-Champ Mah, Mary K. McKenna, Matthew Dysthe, Youngrock Jung, Robin Parihar, Malcolm K. Brenner, Masataka Suzuki
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-01914-8
Popis: Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC xenografts and humanized mouse models.
Databáze: Directory of Open Access Journals
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