| Autor: |
Bo Yu, Ruiping Shi, Chunlai Liu, Zelong Liu, Peihang Shen, Jianglei Hu, Fengwei Shi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 9, Iss 3, Pp e13705- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2023.e13705 |
| Popis: |
This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, respectively. The drug-loaded precursor NH2-SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composites NH2-SBA-16@IMC@GA were synthesized by wrapping the NH2-SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The composition and structure of the drug-loaded composites were characterized by FT-IR, XRD, TG, SEM, TEM, and N2 adsorption-desorption. The in vitro simulated release performance of the drug-loaded composites was investigated at 37 °C under three pH conditions. The results show that the NH2-SBA-16@IMC@GA can be released in response to specific pH environment, which can effectively control the release speed of the indomethacin. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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