| Autor: |
María Elena eErro Aguirre, María Victoria eZelaya, Javier eSánchez Ruiz de Gordoa, María Teresa eTuñón, José Luis eLanciego |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Frontiers in Neuroanatomy, Vol 9 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1662-5129 |
| DOI: |
10.3389/fnana.2015.00025 |
| Popis: |
Objective: To analyze the frequency and distribution of α-synuclein deposits in progressive supranuclear palsy (PSP).Methods: The brains of 25 cases of pathologically confirmed PSP were evaluated with immunohistochemistry for α-synuclein and tau. Multiple immunofluorescent stains were applied to analyze the expression of tau and α-synuclein aggregates in catecholaminergic neurons. Patients’ clinical symptoms were retrospectively recorded. Results: Deposits α-synuclein in the form of typical Lewy bodies (LBs) were only found in two PSP cases (8%) that fulfilled the clinical subtype of PSP known as Richardson’s syndrome (RS). LBs were present in the locus ceruleus, substantia nigra pars compacta, basal forebrain, amygdala and cingulated cortex in a distribution mimicking that of Parkinson’s disease. Triple-immunolabeling revealed co-expression of α-synuclein and tau proteins in some tyrosine hydroxilase-positive neurons of the locus ceruleus and substantia nigra pars compacta.Conclusions: There is no apparent clinical correlation between the presence of LBs in PSP. Tau protein co-aggregate with α-synuclein in catecholaminergic neurons of PSP brains suggesting a synergistic interaction between the two proteins. This is in keeping with the current view of neurodegenerative disorders as ‘misfolded protein diseases’. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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