| Autor: |
Hao Han, Linqi Wang, Tingli Xue, Jie Li, Liyuan Pei, Mingming Zheng |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 94, Iss , Pp 105137- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2022.105137 |
| Popis: |
Lipopolysaccharide (LPS) originating from dysbiotic gut microbiota is regarded as a critical mediator for triggering the inflammation responsible for non-alcoholic fatty liver disease (NAFLD). The preventive effect of plant sterol ester of α-linolenic acid (PS-ALA) on NAFLD was identified in our previous research, yet, the mechanisms linking this effect to gut microbiota and LPS-triggered inflammation remain unclear. In present study, we found that PS-ALA treatment could counteract gut microbial dysbiosis and maintain intestinal barrier function. These beneficial effects of PS-ALA reduced bacterial LPS production and leakage into the portal circulation which attenuated LPS-triggered hepatic inflammation. In addition, PS-ALA inhibited LPS-triggered TLR4/NF-κB signaling pathway activation and reduced pro-inflammatory cytokines release in HepG2 cells. In conclusion, PS-ALA has a dual inhibition effect on endotoxin, including reducing LPS production in the gut and blocking the activation of the LPS-induced TLR4/NF-κB signaling pathway, thereby mitigating inflammatory reactions in the liver and preventing NAFLD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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