Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil
| Autor: | Jean Michell Correia Monteiro, Daniel Lordelo San-Martin, Beatriz Carneiro Gondim Silva, Ian Felipe Barbosa Souza, Jamary Oliveira Filho, Pedro Jesus |
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| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 77, Iss 2, Pp 80-83 |
| Druh dokumentu: | article |
| ISSN: | 1678-4227 0004-282x |
| DOI: | 10.1590/0004-282x20190005 |
| Popis: | ABSTRACT Objectives: To compare warfarin and dabigatran for thromboembolic event prevention in patients with nonvalvular atrial fibrillation or atrial flutter. Methods: This was a retrospective cohort of participants with nonvalvular atrial fibrillation or atrial flutter using either warfarin or dabigatran in a reference center in Brazil. Results: There were 112 patients (mean age 65.5 years), with 55.3% using warfarin. The median duration of follow-up was 1.9 years for warfarin and 1.6 years for dabigatran (p = 0.167). Warfarin patients had a higher median of medical appointments per year (8.3 [6.8-10.4] vs 3.1 [2.3-4.2], p < 0.001) and the frequency of minor bleeding was more than four times higher (17.7% vs 4.0%, p = 0.035). Among patients with prior stroke, those using warfarin had 2.6 times more medical appointments for person-years of follow-up (8.5 vs 3.3). There was no major bleeding or embolic event during follow-up period. Conclusion: The dabigatran group had a lower frequency of minor bleeding and number of medical appointments than the warfarin group, without more embolic events or major bleeding. |
| Databáze: | Directory of Open Access Journals |
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