Prognostic value of microRNA assessment in cervical epithelial cells of patients with mild dysplasia
| Autor: | M. S. Knyazeva, Т. S. Prisyazhnaya, L. M. Zabegina, О. A. Smirnova, A. A. Mikhetko, I. V. Berlev, A. V. Malek |
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| Jazyk: | ruština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Опухоли женской репродуктивной системы, Vol 16, Iss 4, Pp 66-75 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1994-4098 1999-8627 |
| DOI: | 10.17650/1994-4098-2020-16-4-66-75 |
| Popis: | Background. Currently, there are no reliable markers for the prognosis of the low-grade squamous intraepithelial lesion (LSIL) of the cervical epithelium. Scientific literature provides with inconsistent recommendations regarding the management of the young patients with a cytological diagnosis of LSIL. The progression of cervical dysplasia and the development of cervical cancer are associated with characteristic alterations of the microRNA expression profile.Objective: to assess the prognostic value of microRNA in LSIL. Materials and methods. Samples (cytological smears) obtained from patients diagnosed with LSIL (n = 36), but with a different course of the disease over the next 6–12 months. Analysis of miRNA expression was carried out by the method of “two-tailed” reverse transcription and subsequent PCR.Results. The expression level of miR-126, miR-21, miR-1246, miR-182 was statistically significantly different in the compared groups, but the predictive value of the analysis of individual molecules was low (AUC |
| Databáze: | Directory of Open Access Journals |
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