| Autor: |
YANG Xinyu, LI Yanjie, QIN Hewei, LIU Dandan, ZHAO Nannan, JIANG Jingjing |
| Jazyk: |
čínština |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Xiehe Yixue Zazhi, Vol 15, Iss 5, Pp 1124-1130 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1674-9081 |
| DOI: |
10.12290/xhyxzz.2024-0062 |
| Popis: |
Vascular cognitive impairment (VCI) denotes a wide range of cognitive deficiencies resulting from cerebrovascular risk factors and cerebrovascular diseases. Sirtuin 1 (SIRT1), as a deacetylase, can mediate the deacetylation of histones and non-histone proteins. It is involved in regulating multiple pathophysiological processes of VCI, including neuroinflammation reduction, oxidative stress inhibition, cell apoptosis decrease, and blood-brain barrier protection, serving as a target for VCI treatment. This paper summarizes SIRT1 and the molecular mechanisms of targeting SIRT1 in order to provide a reference for the clinical treatment of VCI. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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