Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers

Autor: Longyu Shan, Liang Zhang, Xiaolei Zhu, Zhilin Wang, Shaohan Fang, Junfeng Lin, Jianweng Wang, Ning Li, Hongming Liu, Xiaowen Zhang, Yihui Feng, Jingwei Liu, Jianyun Pan, Guanzhi Ye, Xiuyi Yu, Amanda Tufman, Alexander Katalinic, Torsten Goldmann, Frank Petersen, Jie Jiang, Guojun Geng, Xinhua Yu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Respiratory Research, Vol 23, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1465-993X
DOI: 10.1186/s12931-022-02199-z
Popis: Abstract Background Lung cancers arising in never smokers have been suggested to be substantially different from lung cancers in smokers at an epidemiological, genetic and molecular level. Focusing on non-small cell lung cancer (NSCLC), we characterized lung cancer patients in China looking for demographic and clinical differences between the smoking and never-smoking subgroups. Methods In total, 891 patients with NSCLC, including 841 with adenocarcinoma and 50 with squamous cell carcinoma, were recruited in this study. Association of smoking status with demographic and clinical features of NSCLC was determined, and risk factors for lymph node metastasis and TNM stage were evaluated using Multivariate logistic regression analysis. Results In patients with adenocarcinoma, never smokers showed a younger age at diagnosis (54.2 ± 12.7vs. 59.3 ± 9.4, p adjusted
Databáze: Directory of Open Access Journals
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