Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data
| Autor: | Anna Baran, Paulina Kiluk, Julia Nowowiejska, Tomasz W. Kaminski, Magdalena Maciaszek, Iwona Flisiak |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biology, Vol 11, Iss 1, p 88 (2022) |
| Druh dokumentu: | article |
| ISSN: | 11010088 2079-7737 |
| DOI: | 10.3390/biology11010088 |
| Popis: | Galectin-3 (gal-3) is a multifunctional regulator of various biological processes and diseases, which are common comorbidities in psoriasis. Data regarding potential diagnostic role of gal-3 in psoriasis are insufficient. Serum gal-3 levels were evaluated before and after twelve weeks of treatment with acitretin or methotrexate in 31 patients with plaque-type psoriasis and compared to 11 healthy control group. The mean serum galectin-3 level in patients with psoriasis was significantly higher compared to the control group (p < 0.01). In patients with obesity and long-lasting psoriasis (>20 years) positive relations of gal-3 and PASI were noted. In psoriatics with low gal-3 levels, positive correlations between the gal-3 and BMI, glucose level, and with the latter in short-lasting psoriasis ( |
| Databáze: | Directory of Open Access Journals |
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