| Autor: |
Antonela Del Giúdice, Lucas Pagura, María Celeste Capitani, Leandro Ernesto Mainetti, O Graciela Scharovsky, Ricardo José Di Masso, María José Rico, Viviana Rosa Rozados |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Future Science OA, Vol 6, Iss 10 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2056-5623 |
| DOI: |
10.2144/fsoa-2019-0108 |
| Popis: |
Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
