H/D Exchange Using Hot Heavy Water
| Autor: | Seijiro Matsubara, Kenichi Ishibashi, Gone Yi Thaw Maung, Yuudai Morota, Tomomi Umemura, Yumi Kato |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 72, Iss 12 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| DOI: | 10.2533/chimia.2018.853 |
| Popis: | Metal-catalyzed H/D exchange in hydrothermal deuterium oxide, performed in an autoclave using external heating or in a sealed glass tube under microwave irradiation, was shown to be an efficient method for preparing various deuterium-labeled compounds. Phosphonium salts for the Wittig reaction were deuterated at the ?-position in the presence of MS 4A under microwave irradiation; primary alcohols and primary/secondary amines were deuterated at the ?-position in the presence of ruthenium catalyst under microwave irradiation; metal-catalyzed direct C–H functionalizations on sp3 and sp2 carbon gave the corresponding fully deuterated products under hydrothermal conditions. These methods gave various deuterium-labelled compounds efficiently using D2O as a D-atom source. |
| Databáze: | Directory of Open Access Journals |
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