Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Autor:	Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Science
Zdroj:	Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Druh dokumentu:	article
ISSN:	2041-1723
DOI:	10.1038/s41467-021-25280-5
Popis:	In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ