| Autor: |
Jennifer L. Yates, David S. Palat, M. Kristina Subik, William T. Lee, Kathleen A. McDonough, Edward Conuel |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Clinical Immunology Communications, Vol 2, Iss , Pp 57-61 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2772-6134 |
| DOI: |
10.1016/j.clicom.2022.03.001 |
| Popis: |
Convalescent plasma (CP) has been the first line of defense against numerous infectious diseases throughout history. The COVID-19 pandemic created a need for a quick, easily accessible, and effective treatment for severe disease and CP was able to meet that immediate need. The utility of CP warrants a better understanding of the pharmacokinetics of CP treatment. Here we present the case of a COVID-19 patient with a genetic deficiency in antibody production who received CP as a part of the treatment regimen. In depth serological analysis revealed a surprising lack of SARS-CoV-2 specific antibodies and reduced serum IgG following CP infusion. Our study highlights plasma dilution and accelerated antibody clearance as potential mechanisms for the variable efficacy of CP therapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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