| Autor: |
Zatiye Ayca Cevikelli Yakut, Busra Ertas, Ali Sen, Goksel Sener |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Medicine Science, Vol 9, Iss 2, Pp 404-7 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2147-0634 |
| DOI: |
10.5455/medscience.2019.08.9204 |
| Popis: |
In angiotensin dependent hypertension, high blood pressure and elevated angiotensin 2 levels lead to inflammation by increasing the pro-inflammatory cytokine levels. Since Myrtus communis have showed anti-inflammatory acvtivity in ethnobotanical researches and experimental studies, we investigated the effect of Myrtus communis extract against inflammation in a rat model of angiotensin dependent hypertension. Wistar albino rats were divided as sham-operated control, RVH and Myrtus communis extract-treated RVH groups. Left renal arteries of the rats were implanted with silver clip. Indirect blood pressure measurement of rats was provided with tail-cuff method before the surgery, 3 and 9 weeks after the surgery. Myrtus communis extract (100 mg/kg, orally) or vehicle was administered for 6 weeks. At the end of the study, serum samples were collected to investigate tumor necrosis alpha (TNF-α), interleukin-1 beta (IL-1β) and IL-6 levels. RVH resulted in significant increases in these proinflammatory cytokine levels. In the Myrtus communis extract treatment group, this increasement was abolished. The present data demonstrated that Myrtus communis attenuates RVH-induced inflammation. [Med-Science 2020; 9(2.000): 404-7] |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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