Malfunction of Vascular Control in Lifestyle-Related Diseases: Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
| Autor: | Narumi Hobara, Arisa Nakamura, Mitsuhiro Goda, Hiromu Kawasaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Journal of Pharmacological Sciences, Vol 96, Iss 4, Pp 391-394 (2004) |
| Druh dokumentu: | article |
| ISSN: | 1347-8613 29804337 |
| DOI: | 10.1254/jphs.fmj04006x2 |
| Popis: | The distribution and characteristics of adrenomedullin (AM)-containing perivascular nerves in the rat mesenteric artery were investigated using immunohistochemical techniques. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia of mesenteric arteries, which were densely innervated by calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-LI fibers. AM-LI, CGRP-LI, and NPY-LI fibers were abolished by cold storage denervation. Capsaicin pretreatment abolished AM-LI and NPY-LI fibers but not NPY-LI fibers. NPY-LI fibers but not AM-LI and CGRP-LI fibers disappeared after treatment with 6-hydroxydopamine. There were many AM-LI positive cells in the dorsal root ganglia, where AM mRNA was detected. In a double immunofluorescence study, AM-LI was found in CGRP-LI fibers, although some fibers contained AM-LI alone. The density of AM-LI fibers was lower in SHR than in WKY mesenteric arteries. These results suggest that the mesenteric artery is innervated by AM-containing perivascular nerves and AM may have a neurotransmitter role in the regulation of vascular tone. Keywords:: adrenomedullin, perivascular nerve, rat mesenteric artery, capsaicin-sensitive nerve, spontaneously hypertensive rat |
| Databáze: | Directory of Open Access Journals |
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