Genetic Structure of Plasmodium falciparum and Elimination of Malaria, Comoros Archipelago
| Autor: | Stanislas Rebaudet, Hervé Bogreau, Rahamatou Silaï, Jean-François Lepère, Lionel Bertaux, Bruno Pradines, Jean Delmont, Philippe Gautret, Philippe Parola, Christophe Rogier |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 16, Iss 11, Pp 1686-1694 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid1611.100694 |
| Popis: | The efficacy of malaria control and elimination on islands may depend on the intensity of new parasite inflow. On the Comoros archipelago, where falciparum malaria remains a major public health problem because of spread of drug resistance and insufficient malaria control, recent interventions for malaria elimination were planned on Moheli, 1 of 4 islands in the Comoros archipelago. To assess the relevance of such a local strategy, we performed a population genetics analysis by using multilocus microsatellite and resistance genotyping of Plasmodium falciparum sampled from each island of the archipelago. We found a contrasted population genetic structure explained by geographic isolation, human migration, malaria transmission, and drug selective pressure. Our findings suggest that malaria elimination interventions should be implemented simultaneously on the entire archipelago rather than restricted to 1 island and demonstrate the necessity for specific chemoresistance surveillance on each of the 4 Comorian islands. |
| Databáze: | Directory of Open Access Journals |
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