| Autor: |
Jie Gao, Yun Tian, Xiaolu Xie, Jin Zhao, Chuan-hao Liu, Ying Sheng, Fang Cao |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Anatolian Journal of Cardiology, Vol 23, Iss 1, Pp 35-40 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2149-2263 |
| DOI: |
10.14744/AnatolJCardiol.2019.75332 |
| Popis: |
Objective: The present study aims to investigate the effect of losartan, an selective angiotensin II type 1 receptor (AT1R) blocker, on both the increase of IKs current and shortening of action potential duration (APD) induced by stretch of atrial myocytes, and to uncover the mechanism underlying the treatment of fibrillation (AF) by AT1R blockers. Methods: Hyposmotic solution (Hypo-S) was applied in the guinea pig atrial myocytes to simulate cell stretch, then patch-clamp technique was applied to record the IKs and APD in atrial myocytes. Results: Hypo-S increased the IKs by 105.6%, while Hypo-S+1-20 μM of losartan only increased the IKs by 70.3-75.5% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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