An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke

Autor: Junfeng Wang, Qibing Liu, Yingbo Li, Yi Pang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Pharmaceutical Analysis, Vol 14, Iss 4, Pp 100903- (2024)
Druh dokumentu: article
ISSN: 2095-1779
DOI: 10.1016/j.jpha.2023.11.010
Popis: A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and sensitivity for Zn2+ detection has been developed. This sensor exhibits a large Stokes' shift (∼300 nm) and can be excited from 900 to 1000 nm, with an emission wavelength of ∼785 nm, making it ideal for imaging in biological tissues. The sensor's high selectivity for Zn2+ over other structurally similar cations, such as Cd2+, makes it a promising tool for monitoring zinc ion levels in biological systems. Given the high concentration of zinc in thrombi, this sensor could provide a useful tool for in vivo thrombus imaging.
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