Thiol/disulphide homeostasis, ischemia modified albumin, and ferroxidase as oxidative stress markers in women with obesity with insulin resistance

Autor: Ates Elif, Set Turan, Caner-Karahan Süleyman, Biçer Cemile, Erel Ozcan
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Medical Biochemistry, Vol 38, Iss 4, Pp 445-451 (2019)
Druh dokumentu: article
ISSN: 1452-8258
1452-8266
Popis: Background: The purpose of the study was to determine oxidative stress-related plasma thiol/disulphide, ischemiamodified albumin (IMA) levels and ferroxidase activity among women with obesity in insulin-resistant and noninsulin-resistant groups in comparison with an overweight group. Methods: We compared plasma thiol/disulphide, IMA levels, and ferroxidase activity between the study groups. We analyzed plasma thiol/disulphide homeostasis with a newly developed automated measurement method; IMA with Albumin Cobalt Binding Test and ferroxidase (ceruloplasmin) levels with an automated, colourimetric method. Results: There were no significant differences between insulin-resistant and non-insulin-resistant women with obesity in terms of plasma native thiol, total thiol, disulphide, disulphide/native thiol ratio, disulphide/total thiol or native thiol/total thiol values. Ferroxidase activity was higher in insulin-resistant than in non-insulin-resistant women with obesity and higher in the total women with obesity group than in the overweight subjects (p
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